Recombinant beta-serine-interferon in hairy cell leukemia compared prospectively with results with recombinant alpha-interferon
نویسندگان
چکیده
منابع مشابه
Treatment of hairy cell leukemia with recombinant alpha 2 interferon.
Nine patients with progressive hairy cell leukemia were treated with subcutaneous injections of recombinant alpha 2 interferon (2 to 10 X 10(6) U/m2) three times weekly. Eight patients completed at least eight weeks of treatment and were evaluable; one patient with refractory thrombocytopenia died of an intracerebral hemorrhage after two doses of interferon. Seven of eight patients responded, w...
متن کاملTreatment of Hairy Cell Leukemia With Recombinant Alpha Interferon: I. Quantitative Study of Bone Marrow Changes
Seventeen patients with hairy cell leukemia (HCL) were treated with low doses of recombinant alpha interferon (IFN) for over 4 months. Marked improvement was observed in peripheral blood and bone marrow in 1 5 of 17 patients. Comparison of pretreatment values and hemograms obtained after 4 months of treatment showed a marked decrease in circulating hairy cells (P < .01 ). a decrease in the numb...
متن کاملPleural involvement in hairy cell leukemia response to recombinant interferon-alpha.
Communications to the Editor right eye), and glaucoma of the left eye by raising the episcleral venous pressure. Seven months after heart-lung transplantation, the patient is in good shape and the ophthalmologic complaints have heen completely relieved. Ophthalmologic examination is nearly normal. Only minor glaucoma of the left eye persists. This letter emphasizes the deleterious effects of pr...
متن کاملReconstitution of endogenous interferon a by recombinant interferon in hairy cell leukemia.
Recombinant human IFN alpha (rhIFN-alpha) plays an important role in the treatment of hairy cell leukemia (HCL). However, the mechanisms leading to its beneficial effect are not completely clarified, and there is no information on IFN-alpha gene expression in this disease. Therefore, we investigated the pattern of IFN-alpha gene expression and protein production in HCL and their potential regul...
متن کاملIncidence of response and long-term follow-up in patients with hairy cell leukemia treated with recombinant interferon alpha-2A.
Thirty-five evaluable patients with hairy cell leukemia (HCL) were treated with recombinant interferon alfa-2a (rIFN-alpha 2a), given at a dose of 3 X 10(6) units (U) intramuscularly (IM) daily for 6 months followed by 3 X 10(6) U IM three times a week for an additional 18 months in a single institution study. All treatment was stopped after 24 months. Sixty-nine percent of patients achieved a ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1989
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19890715)64:2<409::aid-cncr2820640212>3.0.co;2-q